Scientific Research
IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.
Preclinical Research
October 2021 | Drug Delivery and Translational Research
Refining the in vitro release test method for a dapivirine‑releasing vaginal ring to match in vivo performance
Murphy DJ, Lim D, Armstrong R, McCoy CF, Dallal Bashi YH, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK. Drug Delivery and Translational Research. Eprint: 2021 Oct 21. https://doi.org/10.1007/...
July 2021 | International Journal of Pharmaceuticals: X
Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel
Bashi YHD, Murphy DJ, McCoy CF, Boyd P, Brown L, Kihara M, Martin F, McMullen N, Kleinbeck K, Dangi B, Spence P, Hansraj B, Devlin B, Malcolm RK. Int J Pharm X. 2021 Jul; 3:100091. doi.org/10.1016/j....
May 2021 | International Journal of Pharmaceutics: X
Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings
McCoy CF, Spence P, Bashi YHD, Murphy DJ, Boyd P, Dangi B, Derrick T, Devlin B, Kleinbeck K, Malcolm RK. Int J Pharm X. 2021 May 1;3:100081. eCollection 2021 Dec.
July 2019 | International Journal of Pharmaceutics
Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers
Bashi YHD, McCoy CF, Murphy D, Boyd P, Spence P, Kleinbeck K, Devlin B, Malcolm RK. International Journal of Pharmaceutics. 26 Jul 2019: epub ahead of print. doi: 10.1016/j.ijpharm.2019.118574.
June 2019 | AAPS PharmSciTech
Novel Application of Hot Melt Extrusion for the Manufacturing of Vaginal Films Containing Microbicide Candidate Dapivirine
Regev G, Patel SK, Moncla BJ, Twist J, Devlin B, Rohan LC. AAPS PharmSciTech 20, no. 6 (26 Jun 2019): 239.
May 2019 | International Journal of Pharmaceutics
Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions
Murphy DJ, McCoy CF, Boyd P, Derrick T, Spence P, Devlin B, Malcolm K. International Journal of Pharmaceutics. 11 May 2019: epub ahead of print. doi.org/10.1016/j.ijpharm.2019.05.027
April 2019 | Pharmaceutics
Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis
Yang H, Li J, Patel SK, Palmer KE, Devlin B, Rohan LC. Pharmaceutics 11, no. 4(16 April 2019): 184
April 2019 | International Journal of Pharmaceutics
Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES
McBride JW, Malcolm RK, Dias N, Cameron D, Offord RE, Hartley O, Kett VL, Devlin B, Boyd P. International Journal of Pharmaceutics. 15 Apr 2019: epub ahead of print. doi.org/10.1016/j.ijpharm.2019.04...
August 2017 | Journal of Pharmaceutical Sciences
Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring
McCoy SF, Murphy DJ, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK. Journal of Pharmaceutical Sciences. 106, no. 8 (Aug 2017): 2015-25.
September 2016 | International Journal of Pharmaceutics
Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel
Boyd P, Fetherston SM, McCoy CF, Major I, Murphy DJ, Kumar S, Holt J, Brimer A, Blanda W, Devlin B, Malcolm RK. International Journal of Pharmaceutics. 511, no. 1 (10 Sept 2016): 619-629.