Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Preclinical Research

July 2019 | International Journal of Pharmaceutics

Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers

Bashi YHD, McCoy CF, Murphy D, Boyd P, Spence P, Kleinbeck K, Devlin B, Malcolm RK. International Journal of Pharmaceutics. 26 Jul 2019: epub ahead of print. doi: 10.1016/j.ijpharm.2019.118574. 

June 2019 | AAPS PharmSciTech

Novel Application of Hot Melt Extrusion for the Manufacturing of Vaginal Films Containing Microbicide Candidate Dapivirine

Regev G, Patel SK, Moncla BJ, Twist J, Devlin B, Rohan LC. AAPS PharmSciTech 20, no. 6 (26 Jun 2019): 239. 

May 2019 | International Journal of Pharmaceutics

Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions

Murphy DJ, McCoy CF, Boyd P, Derrick T, Spence P, Devlin B, Malcolm K. International Journal of Pharmaceutics. 11 May 2019: epub ahead of print.

April 2019 | Pharmaceutics

Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

Yang H, Li J, Patel SK, Palmer KE, Devlin B, Rohan LC. Pharmaceutics 11, no. 4(16 April 2019): 184

April 2019 | International Journal of Pharmaceutics

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES

McBride JW, Malcolm RK, Dias N, Cameron D, Offord RE, Hartley O, Kett VL, Devlin B, Boyd P. International Journal of Pharmaceutics. 15 Apr 2019: epub ahead of print.

August 2017 | Journal of Pharmaceutical Sciences

Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring

McCoy SF, Murphy DJ, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK. Journal of Pharmaceutical Sciences. 106, no. 8 (Aug 2017): 2015-25. 

September 2016 | International Journal of Pharmaceutics

Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel

Boyd P, Fetherston SM, McCoy CF, Major I, Murphy DJ, Kumar S, Holt J, Brimer A, Blanda W, Devlin B, Malcolm RK. International Journal of Pharmaceutics. 511, no. 1 (10 Sept 2016): 619-629.

July 2016 | European Journal of Pharmaceutics and Biopharmaceutics

Development of a multi-layered vaginal tablet containing dapivirine, levonorgestrel and acyclovir for use as a multipurpose prevention technology

McConville C, Major I, Devlin B, Brimer A. European Journal of Pharmaceutics and Biopharmaceutics. 104 (Jul 2016): 171-9. 

April 2016 | AIDS

Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates

Herrera C, Armanasco, N, García-Pérez J, Ziprin P, Olejniczak N,  Alcamí J, Nuttall J, Shattock RJ. AIDS. 30, no. 7 (24 Apr 2016):1015-1025.

March 2016 | AIDS Research and Human Retroviruses

Short Communication: Limited Anti-HIV-1 Activity of Maraviroc in Mucosal Tissues

Fletcher P, Herrera C, Armanasco N, Nuttall J, Shattock RJ. AIDS Research and Human Retroviruses. 32, no. 4(Mar 2016): 334-8.