Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Preclinical Research

February 2010 | European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences

Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir.

Johnson T.J., Gupta K.M., Fabian J., Albrights T.H., Kiser P.F. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 39, no. 4 (2010):...

February 2009 | Antimicrobial Agents and Chemotherapy

Inhibition of HIV-1 infection by the candidate microbicide, dapivirine, a nonnucleoside reverse transcriptase inhibitor.

Fletcher P., Harman S., Azijn H., Armanasco N., Manlow P., Perumal D., de Bethune M-P., Nuttall J., Romano J., Shattock R. Antimicrobial Agents and Chemotherapy 53, no. 2 (2009):487-95.

March 2008 | Antimicrobial Agents and Chemotherapy

Concentrations of dapivirine in the rhesus macaque and rabbit following once daily intravaginal administration of a gel formulation of [14C] dapivirine for 7 days.

Nuttall J.P., Thake D.C., Lewis M.G., Ferkany J.W., Romano J.W., Mitchnick M.A. Antimicrobial Agents and Chemotherapy 52, no. 3(2008) :909-14.

February 2005 | Protein Expression and Purification

Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development.

Colleluori D.M., Tien D., Kang F., Pagliei T., Kuss R., McCormick T., Watson K., McFadden K., Chaiken I., Buckheit R.W., Jr, Romano J.W. Protein Expression and Purification 39, no. 2 (2005): 229-36.

Clinical Research

May 2020 | JAIDS

Performance and Acceptability of the FC2 Female Condom® when Used With and Without a Silicone Placebo Vaginal Ring – A Randomized, Crossover Trial

Nel A, Malherbe M, van Niekerk N, Beksinska M, Greener R, Smit J, Frezieres R, Walsh T. JAIDS. 2020 May 20. doi: 10.1097/QAI.0000000000002408. [Epub ahead of print]

May 2020 | JAIDS

Performance of Male Condoms when Used With and Without a Silicone Placebo Vaginal Ring – A Randomized, Crossover Trial

Nel A, Malherbe M, van Niekerk N, Beksinska M, Greener R, Smit J, Frezieres R, Walsh T. JAIDS. 2020 May 4. doi: 10.1097/QAI.0000000000002397. [Epub ahead of print]

February 2020 | JAIDS

Phase IIa Safety Study of a Vaginal Ring Containing Dapivirine in Adolescent Young Women

Bunge KE, Levy L, Szydlo DW, Zhang J, Gaur AH, Reirden D, Mayer KH, Futterman D, Hoesley C, Hillier SL, Marzinke MA, Hendrix CW, Gorbach PM, Wilson CM, Soto-Torres L, Kapogiannis B, Nel A, Squires KE...

August 2019 | AIDS

Social Harms in Female-INITIATED hiv prevention method RESEARCH: state of the evidence

Montgomery ET, Roberts ST, Nel A, Malherbe M, Torjesen K, Bunge K, et al. AIDS. 2019 Nov 15; 33(14): 2237-2244.

February 2019 | Antimicrobial Agents and Chemotherapy

Pharmacokinetics of Dapivirine Transfer into Blood Plasma, Breast Milk, and Cervicovaginal Fluid of Lactating Women Using the Dapivirine Vaginal Ring

Noguchi LM, Hoesley C, Kelly C, Scheckter R, Bunge K, Nel A, Marzinke MA, Hendrix CW, Dezzutti CS, Hillier SL, Bogen DL, Piper JM, Beigi RH. Antimicrobial Agents and Chemotherapy. 63, vol. 3 (2019...

October 2018 | Clinical Infectious Diseases

Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women

Chen BA, Zhang J, Gundacker HM, Hendrix CW, Hoesley CJ, Salata RA, Dezzutti CS, van der Straten A, Hall WB, Johnson CE, Johnson S, McGowan I, Nel AM, Soto-Torres L, Marzinke MA. Clinical Infectious...

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