Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Clinical Research

October 2018 | Clinical Infectious Diseases

Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women

Chen BA, Zhang J, Gundacker HM, Hendrix CW, Hoesley CJ, Salata RA, Dezzutti CS, van der Straten A, Hall WB, Johnson CE, Johnson S, McGowan I, Nel AM, Soto-Torres L, Marzinke MA. Clinical Infectious...

May 2018 | AIDS and Behavior

Contraceptive Preference Among Women at Risk of HIV Acquisition in a Preparatory Screening Study for a Phase III Microbicide Trial in South Western Uganda

Kusemererwa S, Abaasa A, Onyango M, Nel AM, Isaacs M, Asiki G. AIDS and Behavior. 2018 May 31, doi: 10.1007/s10461-018-2177-3 [epub ahead of print]. 

May 2018 | PLOS ONE

Safety of a silicone elastomer vaginal ring as potential microbicide delivery method in African women: A Phase 1 randomized trial

Nel A, Martins J, Bekker LG, Ramjee G, Masenga G, Rees H, van Niekerk N. PLOS ONE. 2018 May 29; 13(5): e0196904.

December 2016 | New England Journal of Medicine

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

Nel A, van Niekerk N, Kapiga S, Bekker LG, Gama C, Gill K, Kamali A, Kotze P, Louw C, Mabude Z, Miti N, Kusemererwa S, Tempelman H, Carstens H, Devlin B, Isaacs M, Malherbe, Mans W, Nuttall J,...

November 2016 | AIDS and Behavior

Adherence and Acceptability of a Multidrug Vaginal Ring for HIV Prevention in a Phase I Study in the United States

van der Straten A, Panther L, Laborde N, Hoesley CL, Cheng H, Husnik MJ, Horn S, Nel A, Soto-Torres L, Chen BA. AIDS and Behavior. 20, no. 11 (November 2016): 2644-2653.

July 2016 | Medicine

Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial

Dezzutti CS, Richardson-Harman N, Rohan L, Marzinke MA, Hoesley CJ, Panther L, Johnson S, Nuttall JP, Nel A, Chen BA. Medicine 95, no. 8 (2016 Jul): e4174. doi: 10.1097/MD.0000000000004174.

June 2016 | Journal of Pharmaceutical and Biomedical Analysis

Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence

Spence P, Nel A, van Niekerk N, Derrick T, Wilder S, Devlin B. Journal of Pharmaceutical and Biomedical Analysis. 125 (5 Jun 2016): 94-100.

March 2016 | PLOS ONE

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa

Nel A, Bekker LG, Bukusi E, Hellstrӧm, Kotze P, Louw C, Martinson F, Masenga G, Montgomery E, Ndaba N, van der Straten A, van Niekerk N, Woodsong C. PLOS ONE. 10 Mar 2016, doi: 10.1371/journal.pone....

November 2015 | Journal of Acquired Immune Deficiency Syndromes

A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film

Bunge KE, Dezzutti CS, Rohan LC, Hendrix CW, Marzinke MA, Richardson-Harman N, Moncla BJ, Devlin B, Meyn LA, Spiegel HML, Hillier SL. Journal of Acquired Immune Deficiency Syndromes. Epub 2015 Nov 11.

May 2015 | Journal of Acquired Immune Deficiency Syndromes

Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: a Double-Blind Randomized Trial

Chen BA, Panther L, Marzinke MA, Hendrix CW, Hoesley CJ, van der Straten A, Husnik MJ, Soto-Torres L, Nel A, Johnson S, Richardson-Harman, Rabe LK, Dezzutti CS. Journal of Acquired Immune Deficiency...

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