Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Preclinical Research

December 2012 | European Journal of Pharmaceutical Sciences

A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action.

Fetherston SM, Boyd P, McCoy CF, McBride MC, Edwards KL, Ampofo S, Malcolm RK. European Journal of Pharmaceutical Sciences. 48, no. 3 (21 Dec 2012):406-415.

December 2012 | Journal of Chromatography B

Development and validation of a HPLC method for the assay of dapivirine in cell-based and tissue permeability experiments.

das Neves J, Sarmento B, Amiji M, Bahia MF. Journal of Chromatography B. 911 (12 Dec 2012):76-83. Epub 2 Nov 2012.

November 2012 | Molecular Pharmaceutics

Interactions of Microbicide Nanoparticles with a Simulated Vaginal Fluid.

das Neves J, Rocha CMR, Gonçalves MP, Carrier RL, Amiji M, Bahia MF, Sarmento B. Molecular Pharmaceutics. 9, no. 11 (5 November 2012):3347-56. Epub 24 Sept 2012.

June 2012 | Pharmaceutical Research

Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine.

das Neves J, Michiels J, Arien KK, Vanham G, Amiji M, Bahia MF, Sarmento B. Pharmaceutical Research. 29, no. 6 (June 2012): 1468-84. Epub 10 November 2011.

April 2012 | Journal of Pharmaceutical Sciences

Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection

Ham AS, Ugaonkar SR, Shi L, Buckheit KW, Lakougna H, Nagaraja U, Gwozdz G, Goldman L, Kiser PF, Buckheit RW Jr. Journal of Pharmaceutical Sciences. 101, no. 4 (April 2012):1423-35. Epub 6 Jan 2012.

January 2012 | Antimicrobial Agents and Chemotherapy

Pharmacokinetics of Tenofovir following Intravaginal and Intrarectal Administration of Tenofovir Gel to Rhesus Macaques.

Nuttall J, Kashuba A, Wang R, White N, Allen P, Robert J, Romano J. Antimicrobial Agents and Chemotherapy. 56, no. 1 (January 2012):103-9. Epub 10 October 2011.

June 2010 | Journal of Pharmaceutical and Biomedical Analysis

Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles.

das Neves J, Sarmento B, Amiji MM, Bahia MF. Journal of Pharmaceutical and Biomedical Analysis. 52, no. 2 (5 June 2010):167-72. Epub 2010 Jan 15.

March 2010 | International Journal of Pharmaceutics

Freeze-dried, mucoadhesive system for vaginal delivery of the HIV microbicide, dapivirine: optimization by an artificial neural network.

Woolfson A.D., Umrethia M.L., Kett V.L., Malcolm R.K. International Journal of Pharmaceutics 388, no.1-2 (2010):136-143. 

February 2010 | European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences

Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir.

Johnson T.J., Gupta K.M., Fabian J., Albrights T.H., Kiser P.F. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 39, no. 4 (2010):...

February 2009 | Antimicrobial Agents and Chemotherapy

Inhibition of HIV-1 infection by the candidate microbicide, dapivirine, a nonnucleoside reverse transcriptase inhibitor.

Fletcher P., Harman S., Azijn H., Armanasco N., Manlow P., Perumal D., de Bethune M-P., Nuttall J., Romano J., Shattock R. Antimicrobial Agents and Chemotherapy 53, no. 2 (2009):487-95.