Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Preclinical Research

May 2014 | Molecular Pharmaceutics

Increased dapivirine tissue accumulation through vaginal film codelivery of dapivirine and tenofovir

Akil A, Devlin B, Cost M, Rohan LC. Molecular Pharmaceutics. 2014 May 5;11(5):1533-41. Epub 2014 Apr 14.

February 2014 | Journal of Raman Spectroscopy

A process analytical approach for quality control of dapivirine in HIV preventive vaginal rings by Raman spectroscopy

Lyndgaard LB, Spångberg R, Gilmour C, Lyndgaard CB, van den Berg F. Journal of Raman Spectroscopy. 45, no. 2 (Feb 2014):149-56.

January 2014 | Pharmaceutical Research

Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

das Neves J, Araújo F, Andrade F, Amiji M, Bahia MF, Sarmento B. Pharmaceutical Research. Epub ahead of print 22 Jan 2014.

December 2013 | Antiviral Research

Development of dapivirine vaginal ring for HIV prevention

Devlin B, Nuttall J, Wilder S, Woodsong C, Rosenberg Z. Antiviral Research. 100 Suppl (December 2013):S3-8. Epub November 2013.

November 2013 | International Journal of Pharmaceutics

Assessing the physical–chemical properties and stability of dapivirine-loaded polymeric nanoparticles

das Neves J, Amiji M, Bahia MF, Sarmento B. International Journal of Pharmaceutics. 456, no. 2 (18 Nov 2013):307-314. Epub 4 Sep 2013.

July 2013 | Molecular Pharmaceutics

In Vitro and Ex Vivo Evaluation of Polymeric Nanoparticles for Vaginal and Rectal Delivery of the Anti-HIV Drug Dapivirine

das Neves J, Araújo F, Andrade F, Michiels J, Ariën KK, Vanham G, Amiji M, Bahia MF, Sarmento B. Molecular Pharmaceutics. 10, no. 7 (1 Jul 2013):2793-807. Epub 5 June 2013.

May 2013 | Organic Process Research & Development

Synthetic Process Development of BMS-599793 Including Azaindole Negishi Coupling on Kilogram Scale

Pikul S, Cheng H, Cheng A, Huang CD, Ke A, Kuo LH, Thompson A, Wilder S. Organic Process Research & Development. 17, no. 6 (24 May 2013):907-914.

December 2012 | Journal of Chromatography B

Development and validation of a HPLC method for the assay of dapivirine in cell-based and tissue permeability experiments.

das Neves J, Sarmento B, Amiji M, Bahia MF. Journal of Chromatography B. 911 (12 Dec 2012):76-83. Epub 2 Nov 2012.

December 2012 | European Journal of Pharmaceutical Sciences

A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action.

Fetherston SM, Boyd P, McCoy CF, McBride MC, Edwards KL, Ampofo S, Malcolm RK. European Journal of Pharmaceutical Sciences. 48, no. 3 (21 Dec 2012):406-415.

November 2012 | Molecular Pharmaceutics

Interactions of Microbicide Nanoparticles with a Simulated Vaginal Fluid.

das Neves J, Rocha CMR, Gonçalves MP, Carrier RL, Amiji M, Bahia MF, Sarmento B. Molecular Pharmaceutics. 9, no. 11 (5 November 2012):3347-56. Epub 24 Sept 2012.