Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Preclinical Research

July 2015 | Antimicrobial Agents and Chemotherapy

The Sheep as a Model of Preclinical Safety and Pharmacokinetic Evaluations of Candidate Microbicides

Holt JDS, Cameron D, Dias N, Holding J, Muntendam, Oostebring F, Dreier P, Rohan L and Nuttall J. Anitmicrobial Agents and Chemotherapy. 59, no. 7 (July 2015): 3761-3770.

February 2015 | Acta Biomaterialia

Precise engineering of dapivirine-loaded nanoparticles for the development of anti-HIV vaginal microbicides

das Neves J and Sarmento B. Acta Biomaterialia. Epub 17 Feb 2015.

July 2014 | Pharmaceutical Research

Formulation and Characterization of Polymeric Films Containing Combinations of Antiretrovirals (ARVs) for HIV Prevention

Akil A, Agashe H, Dezzutti CS, Moncla BJ, Hillier SL, Devlin B, Shi Y, Uranker K, Rohan LC. Pharmaceutical Research. Epub 31 July 2014.

May 2014 | Molecular Pharmaceutics

Increased dapivirine tissue accumulation through vaginal film codelivery of dapivirine and tenofovir

Akil A, Devlin B, Cost M, Rohan LC. Molecular Pharmaceutics. 2014 May 5;11(5):1533-41. Epub 2014 Apr 14.

February 2014 | Journal of Raman Spectroscopy

A process analytical approach for quality control of dapivirine in HIV preventive vaginal rings by Raman spectroscopy

Lyndgaard LB, Spångberg R, Gilmour C, Lyndgaard CB, van den Berg F. Journal of Raman Spectroscopy. 45, no. 2 (Feb 2014):149-56.

January 2014 | Pharmaceutical Research

Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

das Neves J, Araújo F, Andrade F, Amiji M, Bahia MF, Sarmento B. Pharmaceutical Research. Epub ahead of print 22 Jan 2014.

December 2013 | Antiviral Research

Development of dapivirine vaginal ring for HIV prevention

Devlin B, Nuttall J, Wilder S, Woodsong C, Rosenberg Z. Antiviral Research. 100 Suppl (December 2013):S3-8. Epub November 2013.

November 2013 | International Journal of Pharmaceutics

Assessing the physical–chemical properties and stability of dapivirine-loaded polymeric nanoparticles

das Neves J, Amiji M, Bahia MF, Sarmento B. International Journal of Pharmaceutics. 456, no. 2 (18 Nov 2013):307-314. Epub 4 Sep 2013.

July 2013 | Molecular Pharmaceutics

In Vitro and Ex Vivo Evaluation of Polymeric Nanoparticles for Vaginal and Rectal Delivery of the Anti-HIV Drug Dapivirine

das Neves J, Araújo F, Andrade F, Michiels J, Ariën KK, Vanham G, Amiji M, Bahia MF, Sarmento B. Molecular Pharmaceutics. 10, no. 7 (1 Jul 2013):2793-807. Epub 5 June 2013.

May 2013 | Organic Process Research & Development

Synthetic Process Development of BMS-599793 Including Azaindole Negishi Coupling on Kilogram Scale

Pikul S, Cheng H, Cheng A, Huang CD, Ke A, Kuo LH, Thompson A, Wilder S. Organic Process Research & Development. 17, no. 6 (24 May 2013):907-914.