Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Preclinical Research

August 2017 | Journal of Pharmaceutical Sciences

Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring

McCoy SF, Murphy DJ, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK. Journal of Pharmaceutical Sciences. 106, no. 8 (Aug 2017): 2015-25. 

September 2016 | International Journal of Pharmaceutics

Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel

Boyd P, Fetherston SM, McCoy CF, Major I, Murphy DJ, Kumar S, Holt J, Brimer A, Blanda W, Devlin B, Malcolm RK. International Journal of Pharmaceutics. 511, no. 1 (10 Sept 2016): 619-629.

July 2016 | European Journal of Pharmaceutics and Biopharmaceutics

Development of a multi-layered vaginal tablet containing dapivirine, levonorgestrel and acyclovir for use as a multipurpose prevention technology

McConville C, Major I, Devlin B, Brimer A. European Journal of Pharmaceutics and Biopharmaceutics. 104 (Jul 2016): 171-9. 

April 2016 | AIDS

Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates

Herrera C, Armanasco, N, García-Pérez J, Ziprin P, Olejniczak N,  Alcamí J, Nuttall J, Shattock RJ. AIDS. 30, no. 7 (24 Apr 2016):1015-1025.

March 2016 | AIDS Research and Human Retroviruses

Short Communication: Limited Anti-HIV-1 Activity of Maraviroc in Mucosal Tissues

Fletcher P, Herrera C, Armanasco N, Nuttall J, Shattock RJ. AIDS Research and Human Retroviruses. 32, no. 4(Mar 2016): 334-8. 

March 2016 | Journal of Controlled Release

Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device

Murphy DJ, Boyd P, McCoy CF, Kumar S, Holt JDS, Blanda W, Brimer AN, Malcolm RK. Journal of Controlled Release. 226 (28 Mar 2016): 138-147.

November 2015 | Pharmaceutical Research

Pharmacodynamic Activity of Dapivirine and Maraviroc Single Entity and Combination Topical Gels for HIV-1 Prevention

Dezzutti CS, Yandura S, Wang L, Moncla B, Teeple EA, Devlin B, Nuttall J, Brown ER, Rohan LC. Pharmaceutical Research. 32, no. 11 (Nov 2015):3768-81.

July 2015 | Antimicrobial Agents and Chemotherapy

The Sheep as a Model of Preclinical Safety and Pharmacokinetic Evaluations of Candidate Microbicides

Holt JDS, Cameron D, Dias N, Holding J, Muntendam, Oostebring F, Dreier P, Rohan L and Nuttall J. Anitmicrobial Agents and Chemotherapy. 59, no. 7 (July 2015): 3761-3770.

February 2015 | Acta Biomaterialia

Precise engineering of dapivirine-loaded nanoparticles for the development of anti-HIV vaginal microbicides

das Neves J and Sarmento B. Acta Biomaterialia. Epub 17 Feb 2015.

July 2014 | Pharmaceutical Research

Formulation and Characterization of Polymeric Films Containing Combinations of Antiretrovirals (ARVs) for HIV Prevention

Akil A, Agashe H, Dezzutti CS, Moncla BJ, Hillier SL, Devlin B, Shi Y, Uranker K, Rohan LC. Pharmaceutical Research. Epub 31 July 2014.