Scientific Articles
IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, author, journal name or year published.
Preclinical Research
Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles.
das Neves J, Sarmento B, Amiji MM, Bahia MF. Journal of Pharmaceutical and Biomedical Analysis. 52, no. 2 (5 June 2010):167-72. Epub 2010 Jan 15.
Freeze-dried, mucoadhesive system for vaginal delivery of the HIV microbicide, dapivirine: optimization by an artificial neural network.
Woolfson A.D., Umrethia M.L., Kett V.L., Malcolm R.K. International Journal of Pharmaceutics 388, no.1-2 (2010):136-143.
Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir.
Johnson T.J., Gupta K.M., Fabian J., Albrights T.H., Kiser P.F. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 39, no. 4 (2010):...
Inhibition of HIV-1 infection by the candidate microbicide, dapivirine, a nonnucleoside reverse transcriptase inhibitor.
Fletcher P., Harman S., Azijn H., Armanasco N., Manlow P., Perumal D., de Bethune M-P., Nuttall J., Romano J., Shattock R. Antimicrobial Agents and Chemotherapy 53, no. 2 (2009):487-95.
Concentrations of dapivirine in the rhesus macaque and rabbit following once daily intravaginal administration of a gel formulation of [14C] dapivirine for 7 days.
Nuttall J.P., Thake D.C., Lewis M.G., Ferkany J.W., Romano J.W., Mitchnick M.A. Antimicrobial Agents and Chemotherapy 52, no. 3(2008) :909-14.
Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development.
Colleluori D.M., Tien D., Kang F., Pagliei T., Kuss R., McCormick T., Watson K., McFadden K., Chaiken I., Buckheit R.W., Jr, Romano J.W. Protein Expression and Purification 39, no. 2 (2005): 229-36.
Clinical Research
Acceptability of Vaginal Film, Soft-Gel Capsule, and Tablet as Potential Microbicide Delivery Methods Among African Women.
Nel A., Mitchnick L., Risha P., Muungo LTM., Norick P. Journal of Women's Health 20, no. 8 (August 2011): 1207-1214.
HIV Prevalence and Incidence among Sexually Active Females in Two Districts of South Africa to Determine Microbicide Trial Feasibility.
Nel A., Louw C., Hellstrom E., Braunstein SL., Treadwell I., Marais M., de Villiers M., Hugo J., Paschke I., Andersen C., van de Wijgert J. PLoS ONE 6, no. 8 (August 2011): e21528.
Pharmacokinetic assessment of dapivirine vaginal microbicide gel in healthy, HIV-negative women.
Nel A.M., Coplan P., Smythe S.C., McCord K., Mitchnick M., Romano J. Accepted for publication in AIDS Research and Human Retroviruses. July 2010
Pharmacokinetics of two dapivirine vaginal microbicide gels and their safety vs. hydroxyethyl cellulose-based universal placebo gel.
Nel A., Smythe S., Habibi S., Romano J. Journal of Acquired Immune Deficiency Syndromes. June 2010.