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IPM Product Pipeline

Since our inception in 2002, IPM’s pipeline has included products based on antiretrovirals (ARVs) — the same types of drugs that have proven successful in treating HIV/AIDS and preventing mother-to-child transmission in millions of people around the world.

The pipeline of ARV compounds at IPM is a result of our partnerships with pharmaceutical companies. Through royalty-free licensing agreements, we have access to eight drugs, or active pharmaceutical ingredients, with a variety of mechanisms of action against HIV infection.

The table below provides information on how IPM compounds work and their stage of development at IPM. Our clinical trials page lists IPM clinical trials that are currently under way.

 

Products in Development at IPM
Compound License Mechanism of action IPM development stage
Dapivirine Tibotec/
Johnson & Johnson		 NNRTI: Reverse transcription
  • Phase I/II clinical (dapivirine ring and dapivirine gel)
  • Initiation of safety and efficacy studies planned in 2012 (dapivirine ring)
L167, L872, L882 Merck CCR5: Cell Attachment
  • Preclinical
Tenofovir Gilead NRTI: Reverse transcription 
  • Preclinical* (maraviroc-tenofovir film)
BMS793 BMS gp120: Cell attachment
  • Preclinical (vaginal tablet)
Maraviroc Pfizer CCR5: Cell Attachment
  • Phase I clinical (maraviroc alone and in combination with dapivirine; ring)
  • Preclinical (maraviroc-tenofovir combination film)
L-644 peptide Merck gp41: Cell fusion
  • Early preclinical

* Under development in different stages by other organizations

 

IPM’s active compounds target different steps in viral replication

The candidate microbicides in IPM’s product pipeline target three different steps in the viral replication cycle: attachment, fusion, and reverse transcription.

  • Cell attachment: Preventing the virus from attaching to human cells
  • Cell fusion: Preventing the virus from entering human cells
  • Reverse transcription: Preventing the virus from reproducing inside human cells  

Learn more about how microbicides work.