Maraviroc is marketed under the trade names Selzentry in the United States and Celsentri in Europe for use in combination with other ARVs as an oral treatment for adults with HIV.
How does maraviroc work?
Maraviroc is a CCR5 blocker that works by obstructing a receptor (CCR5) on the surface of cells that is used by the most commonly transmitted strains of HIV-1 to attach to and enter healthy cells. When that receptor is blocked, HIV cannot enter healthy cells.
IPM considers maraviroc a highly promising compound because it is active against HIV strains resistant to other ARVs and is already used safely and effectively to treat HIV/AIDS.
What is maraviroc’s clinical history?
IPM has been developing maraviroc as a microbicide through a 2008 licensing agreement now held by ViiV Healthcare. Because maraviroc is a licensed drug, it came to IPM with an extensive preclinical and clinical safety package as well as data showing its efficacy as a therapeutic.
In what stage of development is maraviroc, and what forms will it take as a microbicide?
IPM has completed a number of preclinical studies of maraviroc, and developed a combination dapivirine-maraviroc vaginal ring that in 2013 was the first combination microbicide ring to enter a Phase I safety study. IPM, in collaboration with Magee-Womens Research Institute, also developed combination vaginal films containing dapivirine and maraviroc, and maraviroc and tenofovir. Maraviroc is also being developed in the field as a rectal microbicide gel.
However, findings from IPM’s research on maraviroc suggest that its efficacy as a microbicide may be limited. IPM has suspended development of maraviroc, in keeping with IPM’s prioritization protocol to put resources behind the ARVs that show the highest likelihood of success as vaginal microbicides. IPM will reassess maraviroc’s potential as a microbicide when additional data from ongoing clinical trials of maraviroc are available.
Where can I get more information?
For information on current clinical trials of maraviroc, visit our Clinical Trials page. For a bibliography of scientific papers and articles on IPM-supported research on maraviroc, visit our Publications & Media page.