ARVs in the Pipeline

IPM's cutting-edge pipeline of ARV compounds is a result of our partnerships with pharmaceutical companies. Through royalty-free licensing agreements for eight ARVs or active pharmaceutical ingredients and exclusive worldwide rights for one ARV called dapivirine, we have access to an array of drugs with a variety of mechanisms of action against HIV infection.

The table below provides information on how IPM compounds work and their stage of development at IPM. Our clinical trials page lists IPM clinical trials that are currently under way.

IPM-licensed ARVs

CompoundLicenseMechanism of actionIPM development stage
DapivirineJanssen Sciences Ireland UC (previously Tibotec)NNRTI: Reverse transcription
  • Clinical: Phase III (dapivirine ring)
  • Phase II- completed    (dapivirine gel)
  • Phase I- ongoing   (dapivirine-darunavir gel)
  • Phase I- completed (dapivirine film)
  • Preclinical (dapivirine-contraceptive ring; dapivirine rectal gel)
DS003 (BMS793)BMSgp120: Cell attachment
  • Clinical: Phase I - ongoing  (DS003 tablet)
  • Preclinical       (DS003-dapivirine ring)
DarunavirJanssen Sciences Ireland UC Protease inhibitor: Protein synthesis and assembly
  • Preclinical  (darunavir-based combination ring)
MaravirocViiV HealthcareCCR5: Cell Attachment
  • Clinical: Phase I- ongoing       (maraviroc vaginal and rectal gels)
  • Phase I- completed (maraviroc ring; dapivirine-maraviroc ring)
TenofovirGileadNRTI: Reverse transcription 
  • Preclinical*
DS001 (L167), DS004 (L872), DS005 (L882)MerckCCR5: Cell Attachment
  • Early preclinical
DS007 (L-644 peptide)Merckgp41: Cell fusion
  • Early preclinical

* Compound is in different stages of development by other organizations


IPM’s active compounds target different steps in viral replication

The candidate microbicides in IPM’s product pipeline target four different steps in the viral replication cycle: attachment, fusion, reverse transcription, and protein synthesis and assembly.

  • Cell attachment: Preventing the virus from attaching to human cells
  • Cell fusion: Preventing the virus from entering human cells
  • Reverse transcription: Preventing the virus from reproducing inside human cells
  • Protein synthesis and assembly: Preventing the virus from producing new virus that can infect healthy cells

Learn more about how microbicides work.